Article

Genetic Prediction of Circulating Lipoprotein(a) Levels in Diverse Populations

2026-02-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Circulating lipoprotein(a) [Lp(a)] levels are highly heritable and linked to atherosclerotic cardiovascular disease, yet clinical measurement rates remain low (<1%) in the United States. The high heritability of Lp(a) across populations makes genetic prediction an attractive approach for closing this testing gap, but existing polygenic scores transfer poorly across populatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c76ecad4-8e3f-521f-8317-dfe9cd2bb72f
DOI: 10.64898/2026.02.20.26346738

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Prediction of Circulating Lipoprotein(a) Levels in Diverse PopulationsDOI 10.64898/2026.02.20.26346738Read

A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease across a diverse cohortSemantic proximity Read

Clinical Utility of Lipoprotein(a) and <i>LPA</i> Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular DiseaseSemantic proximity Read

Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization studySemantic proximity Read

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry.Semantic proximity Read

Polygenic modulation of lipoprotein(a)-associated cardiovascular riskSemantic proximity Read

Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.Semantic proximity Read

A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.Semantic proximity Read

Ancestry specific distribution of LPA Kringle IV-Type-2 genetic variants highlight associations to apo(a) copy number, glucose, and hypertensionSemantic proximity Read

Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.Semantic proximity Read

Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk.Semantic proximity Read

Whole genome sequence analysis of blood lipid levels in >66,000 individualsSemantic proximity Read

Genetic determinants of polygenic prediction accuracy within a population.Semantic proximity Read