Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.

doi:10.1016/j.jacc.2016.10.033

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Article

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.

Journal of the American College of Cardiology - 27 Dec 2016

Emdin Connor A, Khera Amit V, Natarajan Pradeep, Klarin Derek, Won Hong-Hee, Peloso Gina M, Stitziel Nathan O, Nomura Akihiro, Zekavat Seyedeh M, Bick Alexander G, Gupta Namrata, Asselta Rosanna, Duga Stefano, Merlini Piera Angelica, Correa Adolfo, Kessler Thorsten, Wilson James G, Bown Matthew J, Hall Alistair S, Braund Peter S, Samani Nilesh J, Schunkert Heribert, Marrugat Jaume, Elosua Roberto, McPherson Ruth, Farrall Martin, Watkins Hugh, Willer Cristen, Abecasis Gonçalo R, Felix Janine F, Vasan Ramachandran S, Lander Eric, Rader Daniel J, Danesh John, Ardissino Diego, Gabriel Stacey, Saleheen Danish, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has emerged as a therapeutic strategy. Beyond target identification, human genetics may contribute to the development of new therapies by defining the full spectrum of beneficial and adverse...

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PMID: 28007139
DOI: 10.1016/j.jacc.2016.10.033
PMCID: PMC5328146

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