Non-hypermutator cancers access driver mutations through reversals in germline mutational bias

Abstract excerpt

Cancer is an evolutionary disease driven by mutations in asexually-reproducing somatic cells. In asexual microbes, bias reversals in the mutation spectrum can speed adaptation by increasing access to previously undersampled beneficial mutations. By analyzing tumors from 20 tissues, along with normal tissue and the germline, we demonstrate this effect in cancer. Non-hypermutated tumors reverse the germline mutation...

Topics

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• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation Rate
• Neoplasms
• Point Mutation
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

5fee2c3c-45dd-5579-a36e-a7cd64295aa3

DOI

10.1101/2024.04.30.591900