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Article

Optogenetic stimulation of nigral astrocytes is neuroprotective in a 6-OHDA model of neurodegeneration

2025-07-15

Abstract excerpt

<h4>Summary</h4> <h4>Highlights</h4> Optogenetic stimulation of nigral astrocytes attenuates motor deficits & Th+ cell loss in a 6-OHDA model of neurodegeneration Bulk RNA-seq analysis reveals optogenetic stimulation of nigral astrocytes induces early changes in microglia snRNA-seq shows 6-OHDA alone induces extensive gene expression changes across all cell populations within the SN Oligodendrocytes within the S...

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Identifiers and source

Literature Corpus work
5fcbf7d9-f542-5c3a-aff4-c61a9e68dd6d
DOI
10.1101/2025.07.10.664169
Open publication

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Optogenetic stimulation of nigral astrocytes is neuroprotective in a 6-OHDA model of neurodegenerationDOI 10.1101/2025.07.10.664169
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