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Article

Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Nature - 1 Jun 2020

Qian Hao, Kang Xinjiang, Hu Jing, Zhang Dongyang, Liang Zhengyu, Meng Fan, Zhang Xuan, Xue Yuanchao, Maimon Roy, Dowdy Steven F, Devaraj Neal K, Zhou Zhuan, Mobley William C, Cleveland Don W, Fu Xiang-Dong

Abstract excerpt

Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here we report an...

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Identifiers

PMID: 32581380
DOI: 10.1038/s41586-020-2388-4
PMCID: PMC7521455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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