Article

Therapeutic Reversal of Chemically Induced Parkinson Disease by Converting Astrocytes into Nigral Neurons

2020-04-07

Abstract excerpt

<h4>SUMMARY</h4> Parkinson disease is characterized by loss of dopamine neurons in the substantia nigra. As with other neurodegenerative diseases, no disease-modifying treatments exist. While most treatment objectives aim to prevent neuronal loss or protect vulnerable neuronal circuits, an important alternative is to replace lost neurons to reconstruct disrupted circuits. Herein we report an efficient single-step...

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Literature Corpus work: 58f3f6f5-df52-5d4f-b044-8f2b94e9ef14
DOI: 10.1101/2020.04.06.028084

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