Article

The tri-culture system reveals an activation cascade from microglia through astrocytes to neurons during neuroinflammation

2025-07-31

Abstract excerpt

Neuroinflammation is involved in various neurodegenerative diseases, with glial cells playing crucial roles. It is known that neuroinflammation is initiated by microglia, which interact with astrocytes and neurons. However, the detailed molecular mechanisms underlying intercellular interactions during neuroinflammation are not fully understood. To elucidate these mechanisms, multicellular culture systems are requi...

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Literature Corpus work: a25fc857-3cad-5f07-ac2d-05544812f28c
DOI: 10.1101/2025.07.27.667064

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