Article

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3

2025-08-31

Abstract excerpt

<h4>ABSTRACT</h4> EML4-ALK is a common oncogenic driver of non-small cell lung cancer. Distinct EML4-ALK variants cause different rates of disease progression, with patients expressing variant 3 (V3) exhibiting accelerated metastasis. Cells expressing EML4-ALK V3 develop a mesenchymal-like morphology and enhanced migration that is dependent on the NEK9 and NEK7 kinases. However, downstream substrates of these kin...

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Literature Corpus work: 5fb4c61c-bc7f-5318-a2b1-62deadbf81cf
DOI: 10.1101/2025.08.30.672807

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