Article

EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer

2019-03-04

Abstract excerpt

<h4>ABSTRACT</h4> EML4-ALK is an oncogenic fusion present in ∼5% lung adenocarcinomas. However, distinct EML4-ALK variants differ in the length of the EML4 microtubule-associated protein encoded within the fusion and are associated with a poorly understood variability in disease progression and therapeutic response. Here, we show that EML4-ALK variant 3, which is linked to accelerated metastatic spread and worse...

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Literature Corpus work: 53bec8cd-d296-5fec-9c4d-86b4f48248c5
DOI: 10.1101/567305

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