Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic BRAF-Mediated Melanoma Cell Invasion

1 May 2016

Abstract excerpt

Melanoma patients with oncogenic BRAF(V600E) mutation have poor prognoses. While the role of BRAF(V600E) in tumorigenesis is well established, its involvement in metastasis that is clinically observed in melanoma patients remains a topic of debate. Here, we show that BRAF(V600E) melanoma cells have extensive invasion activity as assayed by the generation of F-actin and cortactin foci that mediate membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cutaneous Melanoma Detection and Management
Share to HER2/EGFR in Cancer Research
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27210749
DOI: 10.1016/j.celrep.2016.04.073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic BRAF-Mediated Melanoma Cell InvasionPMID 27210749Read ↗

Melanoma invasion – current knowledge and future directionsSemantic proximity Read ↗

Tumorigenesis driven by the BRAF <sup>V600E</sup> oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasionSemantic proximity Read ↗

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration.Semantic proximity Read ↗

Metastasis suppressor <scp>NME</scp>1 regulates melanoma cell morphology, self‐adhesion and motility via induction of fibronectin expressionSemantic proximity Read ↗

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and MetastasisSemantic proximity Read ↗

Melanoma Proteoglycan Modifies Gene Expression to Stimulate Tumor Cell Motility, Growth, and Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

A Gene Expression Signature of Invasive Potential in Metastatic Melanoma CellsSemantic proximity Read ↗

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanomaSemantic proximity Read ↗

Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.Semantic proximity Read ↗

SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma.Semantic proximity Read ↗

Vemurafenib Drives Epithelial-to-Mesenchymal Transition Gene Expression in BRAF Inhibitor‒Resistant BRAFV600E/NRASQ61K Melanoma Enhancing Tumor Growth and Metastasis in a Bioluminescent Murine Model.Semantic proximity Read ↗

BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.