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Article

Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.

Cells - 13 Jun 2022

Avila-Zozaya Monserrat, Rodríguez-Hernández Brenda, Monterrubio-Ledezma Feliciano, Cisneros Bulmaro, Boucard Antony A

Abstract excerpt

Cancer progression relies on cellular transition states accompanied by changes in the functionality of adhesion molecules. The gene for adhesion G protein-coupled receptor latrophilin-3 (aGPCR Lphn3 or ADGRL3) is targeted by tumor-specific somatic mutations predominantly affecting the conserved GAIN domain where most aGPCRs are cleaved. However, it is unclear how these GAIN domain-altering mutations impact Lphn3...

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Identifiers

PMID: 35741042
DOI: 10.3390/cells11121913
PMCID: PMC9221416

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