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Article

Cortactin in cell migration and cancer at a glance

1 Apr 2012

Abstract excerpt

The actin-nucleation-promoting factor cortactin has emerged not only as a crucial regulator of actin cytoskeletal dynamics, but also as a key player in aggressive cancers (Buday and Downward, 2007; Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical actin structures (Wu et al.,...

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PMID: 22566665
DOI: 10.1242/jcs.093781

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