Article
Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration.
Cell reports - 13 Jul 2021
Huang Hao, Gont Alexander, Kee Lynn, Dries Ruben, Pfeifer Kathrin, Sharma Bandana, Debruyne David N, Harlow Matthew, Sengupta Satyaki, Guan Jikui, Yeung Caleb M, Wang Wenchao, Hallberg Bengt, Palmer Ruth H, Irwin Meredith S, George Rani E
Abstract excerpt
Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear. Both WT and mutant proteins undergo extracellular domain (ECD) cleavage. Here, we map the cleavage site to Asn654-Leu655 and demonstrate that cleavage inhibition of WT ALK...
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