Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.

The Journal of biological chemistry - 11 Jun 2010

Faoro Leonardo, Singleton Patrick A, Cervantes Gustavo M, Lennon Frances E, Choong Nicholas W, Kanteti Rajani, Ferguson Benjamin D, Husain Aliya N, Tretiakova Maria S, Ramnath Nithya, Vokes Everett E, Salgia Ravi

Abstract excerpt

Non-small cell lung cancer (NSCLC) has a poor prognosis and improved therapies are needed. Expression of EphA2 is increased in NSCLC metastases. In this study, we investigated EphA2 mutations in NSCLC and examined molecular pathways involved in NSCLC. Tumor and cell line DNA was sequenced. One EphA2 mutation was modeled by expression in BEAS2B cells, and functional and biochemical studies were conducted. A G391R...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesions

Share to Intracellular Signaling Peptides and Proteins

Share to Neoplasm Invasiveness

Share to Oligonucleotide Array Sequence Analysis

Share to Protein Serine-Threonine Kinases

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 20360610
DOI: 10.1074/jbc.M109.075085
PMCID: PMC2881783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.PMID 20360610Read ↗

Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLCSemantic proximity Read ↗

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung CancerSemantic proximity Read ↗

Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer.Semantic proximity Read ↗

Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma.Semantic proximity Read ↗

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.Semantic proximity Read ↗

Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1.Semantic proximity Read ↗

Effects of cancer-associated EPHA3 mutations on lung cancer.Semantic proximity Read ↗

B7-H3-Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns.Semantic proximity Read ↗

The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomasSemantic proximity Read ↗

Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell linesSemantic proximity Read ↗

Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer.Semantic proximity Read ↗

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.