Article

Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging

2021-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Age-related loss of cellular function and increased cell death are characteristic hallmarks of aging. While defects in gene expression and RNA metabolism have been linked with age-associated human neuropathies, it is not clear how the changes that occur in aging neurons contribute to loss of gene expression homeostasis. R-loops are RNA-DNA hybrids that typically form co-transcriptionally via ann...

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Literature Corpus work: 5faaf4b0-f76d-5f39-92a6-ffd18ec2859c
DOI: 10.1101/2021.06.29.450380

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