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Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection.

mBio - 30 Aug 2022

Alden Katy M, Jezewski Andrew J, Beattie Sarah R, Fox David, Krysan Damian J

Abstract excerpt

Cryptococcus neoformans is an important human fungal pathogen for which the external environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA metabolism enzymes, ATP-citrate lyase (ACL1) and acetyl-CoA synthetase (ACS1), play important roles in C. neoformans infection. Here, we took a genetic interaction approach to studying the interplay between these two enzymes along with an...

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PMID: 35766403
DOI: 10.1128/mbio.01279-22
PMCID: PMC9426453

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