Article

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining

2025-10-09

Abstract excerpt

Invasive fungal infections claim over two million lives annually, a problem exacerbated by rising resistance to current antifungal treatments and an increasing population of immunocompromised individuals. Despite this, antifungal drug development has stagnated, with few novel agents and fewer novel targets explored in recent decades. Here, we validate acetolactate synthase (ALS), an enzyme critical for branched-ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 278297b6-c681-5200-bc50-ca2529eb87fd
DOI: 10.1101/2025.10.09.681488

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome miningDOI 10.1101/2025.10.09.681488Read

Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.Semantic proximity Read

Microbial bioprospecting for benzoxazolinate-like molecules: unleashing the potential of genome miningSemantic proximity Read

Pattern-based genome mining guides discovery of the antibiotic indanopyrrole A from a marine streptomyceteSemantic proximity Read

Mining for a new class of fungal natural products: the evolution, diversity, and distribution of isocyanide synthase biosynthetic gene clustersSemantic proximity Read

Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.Semantic proximity Read

An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomesSemantic proximity Read

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targetsSemantic proximity Read

Genomic mining for Aspergillus natural products.Semantic proximity Read

Whole genome sequencing of newly emerged fungal pathogen <i>Aspergillus lentulus</i> and its Azole resistance gene predictionSemantic proximity Read

Pattern-Based Genome Mining Guides Discovery of the Antibiotic Indanopyrrole A from a Marine StreptomyceteSemantic proximity Read

Aspergillus fumigatus from Pathogenic Fungus to Unexplored Natural Treasure: Changing the ConceptSemantic proximity Read

ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome miningSemantic proximity Read