Article

Metabolic adaptations underpin resistance to histone acetyltransferase inhibition

2022-08-12

Abstract excerpt

Histone acetyltransferases (HAT) catalyze the acylation of lysine side chains and are implicated in diverse human cancers as both oncogenes and non-oncogene dependencies 1 . Acetyl-CoA-competitive HAT inhibitors have garnered attention as potential cancer therapeutics and the first clinical trial for this class is ongoing ( NCT04606446 ). Despite broad enthusiasm for these targets, notably including CBP/p300 and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7057d96f-2e73-5f97-bda0-c68bcac4884e
DOI: 10.1101/2022.08.12.503669

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic adaptations underpin resistance to histone acetyltransferase inhibitionDOI 10.1101/2022.08.12.503669Read

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cellsSemantic proximity Read

Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success.Semantic proximity Read

Evolved, Selective Erasers of Distinct Lysine AcylationsSemantic proximity Read

Interrupting ELMSAN1 repression of nuclear acetyl-CoA production therapeutically reprograms cancer cellsSemantic proximity Read

A feedforward loop between ACLY and MYC supports T-ALL progression in vivoSemantic proximity Read

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and preventionSemantic proximity Read

ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid LeukemiaSemantic proximity Read

Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitorsSemantic proximity Read

Targeting ACSS2 activity suspends the formation of chemoresistance through suppressed histone H3 acetylation in human breast cancerSemantic proximity Read

Discovery and mechanism of a highly selective, antifungal acetyl CoA synthetase inhibitorSemantic proximity Read

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.Semantic proximity Read

Multi-omic profiling of tyrosine kinase inhibitor-resistant K562 cells suggests metabolic reprogramming to promote cell survivalSemantic proximity Read