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Article

Arylamine N-acetyltransferases: From Structure to Function

1 Jan 2008

Abstract excerpt

Arylamine N-acetyltransferases (NATs) are cytosolic conjugating enzymes which transfer an acetyl group from acetylCoenzyme A to a xenobiotic acceptor substrate. The enzyme has an active site cysteine as part of a catalytic triad with histidine and aspartate. NATs have had an important role in pharmacogenetics. Polymorphism in acetylation (and inactivation) of the anti-tubercular agent isoniazid resides in human...

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PMID: 18642144
DOI: 10.1080/03602530802186603

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