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Increased Mitochondrial Calcium Uptake and Concomitant Hyperactivity by Presenilin Loss Promotes mTORC1 Signaling to Drive Neurodegeneration

2020-12-08

Abstract excerpt

<title>Abstract</title> <p>BackgroundMetabolic dysfunction and protein aggregation are common characteristics that occur in age-related neurodegenerative disease, such as Alzheimer’s disease (AD). However, the mechanisms underlying these abnormalities remain poorly understood. Mutations in the presenilin genes are the primary cause of early onset familial AD, but despite their identification over 20 years ago, th...

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Literature Corpus work
03156bd1-4f40-5985-857e-c24b09d04e66
DOI
10.21203/rs.3.rs-120594/v1
Open publication

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Increased Mitochondrial Calcium Uptake and Concomitant Hyperactivity by Presenilin Loss Promotes mTORC1 Signaling to Drive NeurodegenerationDOI 10.21203/rs.3.rs-120594/v1
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