Article

Divergent Biological Consequences of APOE Isoforms Across Industrialized and Non-Industrial Environments

2026-02-26

Abstract excerpt

The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in industrialized settings; nevertheless, APOE ε4—which is ancestral in humans—has persisted over evolutionary time. One potential explanation is that the costs and benefits of APOE ε4 were significantly different in the environments in whi...

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Literature Corpus work: 5f717e39-342e-5021-ace7-0c2e10e283e4
DOI: 10.64898/2026.02.24.706846

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