Article
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population.
eLife - 29 Sept 2021
Garcia Angela R, Finch Caleb, Gatz Margaret, Kraft Thomas, Eid Rodriguez Daniel, Cummings Daniel, Charifson Mia, Buetow Kenneth, Beheim Bret A, Allayee Hooman, Thomas Gregory S, Stieglitz Jonathan, Gurven Michael D, Kaplan Hillard, Trumble Benjamin C
Abstract excerpt
In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when...
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