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Article

COVID-19 enters the expanding network of apolipoprotein E4-related pathologies.

Redox biology - 1 May 2021

Gkouskou Kalliopi, Vasilogiannakopoulou Theodora, Andreakos Evangelos, Davanos Nikolaos, Gazouli Maria, Sanoudou Despina, Eliopoulos Aristides G

Abstract excerpt

COVID-19 incidence and case fatality rates (CFR) differ among ethnicities, stimulating efforts to pinpoint genetic factors that could explain these phenomena. In this regard, the multiallelic apolipoprotein E (APOE) gene has recently been interrogated in the UK biobank cohort, demonstrating associations of the APOE ε4/ε4 genotype with COVID-19 severity and mortality. The frequency of the ε4 allele and thus the...

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Identifiers

PMID: 33730676
DOI: 10.1016/j.redox.2021.101938
PMCID: PMC7943392

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