Article
Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Dec 2007
Huebbe P, Jofre-Monseny L, Boesch-Saadatmandi Ch, Minihane A-M, Rimbach G
Abstract excerpt
The aetiology of apoE4 genotype-Alzheimer's disease (AD) association are complex. The current study emphasizes the impact of apoE genotype and potential beneficial effects of vitamin E (VE) in relation to oxidative stress. Agonist induced neuronal cell death was examined 1) in the presence of conditioned media containing equal amounts of apoE3 or apoE4 obtained from stably transfected macrophages, and 2) after...
Topics
- Analysis of Variance
- Animals
- Antioxidants
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Biomarkers
- Brain
- Cell Death
- Cell Line, Tumor
- Female
- Genotype
- Humans