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Article

Effect of APOE ε4 allele on survival and fertility in an adverse environment.

PloS one - 1 Jan 2017

van Exel Eric, Koopman Jacob J E, Bodegom David van, Meij Johannes J, Knijff Peter de, Ziem Juventus B, Finch Caleb E, Westendorp Rudi G J

Abstract excerpt

BACKGROUND: The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental outcomes in affluent populations including atherosclerotic disease, Alzheimer's disease, and reduced lifespan. Despite these detrimental outcomes, population frequencies of APOE-ε4 are high. We hypothesize that the high frequency of APOE-ε4 was maintained because of beneficial effects during evolution when infectious...

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Identifiers

PMID: 28683096
DOI: 10.1371/journal.pone.0179497
PMCID: PMC5500260

Genes

APOE

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