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Article

Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies.

American journal of human genetics - 7 Nov 2024

Chen Yu, Liu Sihan, Ren Zongyao, Wang Feiran, Liang Qiuman, Jiang Yi, Dai Rujia, Duan Fangyuan, Han Cong, Ning Zhilin, Xia Yan, Li Miao, Yuan Kai, Qiu Wenying, Yan Xiao-Xin, Dai Jiapei, Kopp Richard F, Huang Jufang, Xu Shuhua, Tang Beisha, Wu Lingqian, Gamazon Eric R, Bigdeli Tim, Gershon Elliot, Huang Hailiang, Ma Chao, Liu Chunyu, Chen Chao

Abstract excerpt

Research on brain expression quantitative trait loci (eQTLs) has illuminated the genetic underpinnings of schizophrenia (SCZ). Yet most of these studies have been centered on European populations, leading to a constrained understanding of population diversities and disease risks. To address this gap, we examined genotype and RNA-seq data from African Americans (AA, n = 158), Europeans (EUR, n = 408), and East...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39362218
DOI: 10.1016/j.ajhg.2024.09.001
PMCID: PMC11568756

Genes

CNNM2
DENR
FTCDNL1
MPHOSPH9
MTRFR
NT5DC2
SFXN2
VPS37B

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