Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide meta-analyses of cross substance use disorders in diverse populations.

Molecular psychiatry - 1 Mar 2026

Lai Dongbing, Zhang Michael, Green Nick, Abreu Marco, Schwantes-An Tae-Hwi, Parker Clarissa C, Zhang Shanshan, Jin Fulai, Sun Anna, Zhang Pengyue, Edenberg Howard J, Liu Yunlong, Foroud Tatiana

Abstract excerpt

Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Substance-Related Disorders

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 41057643
DOI: 10.1038/s41380-025-03294-5
PMCID: PMC12916498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide meta-analyses of cross substance use disorders in diverse populations.PMID 41057643Read ↗

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disordersSemantic proximity Read ↗

Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.Semantic proximity Read ↗

Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic ScoresSemantic proximity Read ↗

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Semantic proximity Read ↗

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Semantic proximity Read ↗

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.Semantic proximity Read ↗

Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.Semantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

Multi-ancestry genome-wide association study and meta-analysis of stimulant use disorder reveals biology and relationships to other psychiatric disordersSemantic proximity Read ↗

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.Semantic proximity Read ↗

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million IndividualsSemantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.