Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.

doi:10.1038/s41591-023-02653-5

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Article

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.

Nature medicine - 1 Dec 2023

Zhou Hang, Kember Rachel L, Deak Joseph D, Xu Heng, Toikumo Sylvanus, Yuan Kai, Lind Penelope A, Farajzadeh Leila, Wang Lu, Hatoum Alexander S, Johnson Jessica, Lee Hyunjoon, Mallard Travis T, Xu Jiayi, Johnston Keira J A, Johnson Emma C, Nielsen Trine Tollerup, Galimberti Marco, Dao Cecilia, Levey Daniel F, Overstreet Cassie, Byrne Enda M, Gillespie Nathan A, Gordon Scott, Hickie Ian B, Whitfield John B, Xu Ke, Zhao Hongyu, Huckins Laura M, Davis Lea K, Sanchez-Roige Sandra, Madden Pamela A F, Heath Andrew C, Medland Sarah E, Martin Nicholas G, Ge Tian, Smoller Jordan W, Hougaard David M, Børglum Anders D, Demontis Ditte, Krystal John H, Gaziano J Michael, Edenberg Howard J, Agrawal Arpana, Justice Amy C, Stein Murray B, Kranzler Henry R, Gelernter Joel

Abstract excerpt

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries). We...

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Identifiers

PMID: 38062264
DOI: 10.1038/s41591-023-02653-5
PMCID: PMC10719093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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