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Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

Addiction biology - 1 Jun 2023

Holen Børge, Shadrin Alexey A, Icick Romain, Filiz Tahir T, Hindley Guy, Rødevand Linn, O'Connell Kevin S, Hagen Espen, Frei Oleksandr, Bahrami Shahram, Cheng Weiqiu, Parker Nadine, Tesfaye Markos, Jahołkowski Piotr, Karadag Naz, Dale Anders M, Djurovic Srdjan, Smeland Olav B, Andreassen Ole A

Abstract excerpt

Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly heritable, their shared genetic vulnerabilities remain unaccounted for. We applied the conditional/conjunctional false discovery rate (cond/conjFDR) approach to analyse summary statistics from independent...

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Identifiers

PMID: 37252880
DOI: 10.1111/adb.13282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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