Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

doi:10.1038/s41380-022-01709-1

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Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Molecular psychiatry - 1 Oct 2022

Deak Joseph D, Zhou Hang, Galimberti Marco, Levey Daniel F, Wendt Frank R, Sanchez-Roige Sandra, Hatoum Alexander S, Johnson Emma C, Nunez Yaira Z, Demontis Ditte, Børglum Anders D, Rajagopal Veera M, Jennings Mariela V, Kember Rachel L, Justice Amy C, Edenberg Howard J, Agrawal Arpana, Polimanti Renato, Kranzler Henry R, Gelernter Joel

Abstract excerpt

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included...

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PMID: 35879402
DOI: 10.1038/s41380-022-01709-1
PMCID: PMC9718667

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