Article

Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

2023-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Personalized cancer therapeutics bring directed treatment options to patients based on the genetic signatures of their tumors. Unfortunately, tumor genomes are remarkably adaptable, and acquired resistance to these drugs through genetic means is an all-too-frequent occurrence. Identifying mutations that promote resistance within drug-treated patient populations can be cost, resource, and time in...

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Literature Corpus work: 5f34c903-ba11-587b-9168-62582f8307f4
DOI: 10.1101/2023.10.25.564011

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