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Article

Potential biomarkers of DNA replication stress in cancer.

Oncotarget - 6 Jun 2017

Ren Liqun, Chen Long, Wu Wei, Garribba Lorenza, Tian Huanna, Liu Zihui, Vogel Ivan, Li Chunhui, Hickson Ian D, Liu Ying

Abstract excerpt

Oncogene activation is an established driver of tumorigenesis. An apparently inevitable consequence of oncogene activation is the generation of DNA replication stress (RS), a feature common to most cancer cells. RS, in turn, is a causal factor in the development of chromosome instability (CIN), a near universal feature of solid tumors. It is likely that CIN and RS are mutually reinforcing drivers that not only...

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Identifiers

PMID: 28445142
DOI: 10.18632/oncotarget.16940
PMCID: PMC5514887

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