Article

Genetically proxied inhibition of interleukin-6 signaling: opposing associations with susceptibility to COVID-19 and pneumonia

2020-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The inflammatory cytokine interleukin-6 (IL-6) is pivotal for orchestrating the immune response. Inhibitors of IL-6 signaling are being investigated as treatments for severe coronavirus disease 2019 (COVID-19). We conducted a Mendelian randomization study investigating the effect of IL-6 signaling on susceptibility to COVID-19 and pneumonia. Our results showed that genetically proxied inhibition...

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Literature Corpus work: 5f173c89-80db-5c60-af49-9434c2c7aab2
DOI: 10.1101/2020.09.15.20165886

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