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Article

Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.

Cytokine - 1 Dec 2021

Smieszek Sandra P, Przychodzen Bartlomiej P, Polymeropoulos Vasilios M, Polymeropoulos Christos M, Polymeropoulos Mihael H

Abstract excerpt

BACKGROUND: Elevated Interleukin-6 (IL-6) may play an important role in the pathophysiology of COVID-19 yet attenuated response is not seen across all severe patients. We aimed to determine the effect of IL-6 baseline levels and other clinical variables on mortality and outcomes in hospitalized COVID-19 patients as well as to explore genetic variants associated with attenuated IL-6 response. METHODS: Baseline...

Topics

Alleles
COVID-19
Heterozygote
Humans
Interleukin-6
Polymorphism, Single Nucleotide
Receptors, Interleukin-6

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34353696
DOI: 10.1016/j.cyto.2021.155662
PMCID: PMC8318728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34353696-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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