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Article

Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization.

Immunogenetics - 26 Nov 2024

Li Jiaxin, Liu Yalin, Xiao Zheng, Zang Chenyang, Li Peihong, Xiao Bo, Zhou Luo

Abstract excerpt

The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs); however, the underlying therapeutic efficacy associated with this approach remains elusive. We conducted a comprehensive Mendelian randomization (MR) analysis based on large-scale genome-wide association studies to investigate the causal relationships between genetically proxied IL-6R...

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PMID: 39589413
DOI: 10.1007/s00251-024-01360-w

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