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Article

Pathway-Based Mendelian Randomization for Pre-Infection IL-6 Levels Highlights Its Role in Coronavirus Disease.

Genes - 6 Jul 2024

Kamali Zoha, Esmaeil Nafiseh, Thio Chris H L, Vaez Ahmad, Snieder Harold

Abstract excerpt

OBJECTIVES: Interleukin 6 (IL-6) levels at hospital admission have been suggested for disease prognosis, and IL-6 antagonists have been suggested for the treatment of patients with severe COVID-19. However, less is known about the relationship between pre-COVID-19 IL-6 levels and the risk of severe COVID-19. To fill in this gap, here we extensively investigated the association of genetically instrumented IL-6...

Topics

Humans
Interleukin-6
COVID-19
Mendelian Randomization Analysis
Receptors, Interleukin-6
SARS-CoV-2
Biomarkers
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39062668
DOI: 10.3390/genes15070889
PMCID: PMC11275426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39062668-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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