Article

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of <i>EGFR</i>

2020-08-28

Abstract excerpt

<h4>Background</h4> Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the EGFR gene have recently been identified in a distinct subset of pediatric bithalamic gliomas with a unique DNA methylation pattern. <h4>Methods</h4> Here, we investigated an epigenetically homogeneous cohort of malignant gliomas (n=58) distinct...

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Literature Corpus work: 5f10b7c1-8895-5a1d-8cc7-fa55f2d0b760
DOI: 10.1101/2020.08.28.239160

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