Article
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
Acta neuropathologica - 1 Jun 2020
Mondal Gourish, Lee Julieann C, Ravindranathan Ajay, Villanueva-Meyer Javier E, Tran Quynh T, Allen Sariah J, Barreto Jairo, Gupta Rohit, Doo Pamela, Van Ziffle Jessica, Onodera Courtney, Devine Patrick, Grenert James P, Samuel David, Li Rong, Metrock Laura K, Jin Lee-Way, Antony Reuben, Alashari Mouied, Cheshier Samuel, Whipple Nicholas S, Bruggers Carol, Raffel Corey, Gupta Nalin, Kline Cassie N, Reddy Alyssa, Banerjee Anu, Hall Matthew D, Mehta Minesh P, Khatib Ziad, Maher Ossama M, Brathwaite Carole, Pekmezci Melike, Phillips Joanna J, Bollen Andrew W, Tihan Tarik, Lucas John T, Broniscer Alberto, Berger Mitchel S, Perry Arie, Orr Brent A, Solomon David A
Abstract excerpt
Brain tumors are the most common solid tumors of childhood, and the genetic drivers and optimal therapeutic strategies for many of the different subtypes remain unknown. Here, we identify that bithalamic gliomas harbor frequent mutations in the EGFR oncogene, only rare histone H3 mutation (in contrast to their unilateral counterparts), and a distinct genome-wide DNA methylation profile compared to all other...
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