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Article

Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas.

Acta neuropathologica - 1 Feb 2016

Broniscer Alberto, Chamdine Omar, Hwang Scott, Lin Tong, Pounds Stanley, Onar-Thomas Arzu, Shurtleff Sheila, Allen Sariah, Gajjar Amar, Northcott Paul, Orr Brent A

Abstract excerpt

Gliomatosis cerebri (GC), a rare and deadly CNS neoplasm characterized by involvement of at least three cerebral lobes, predominantly affects adults. While a few small series have reported its occurrence in children, little is known about the molecular characteristics of pediatric GC. We reviewed clinical, radiological, and histological features of pediatric patients with primary GC treated at our institution...

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Source

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Identifiers

PMID: 26744350
DOI: 10.1007/s00401-015-1532-y
PMCID: PMC4886851

Genes

BRAF
IDH1
PDGFRA
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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