Article
A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.
Neuro-oncology - 30 Jan 2021
Sievers Philipp, Sill Martin, Schrimpf Daniel, Stichel Damian, Reuss David E, Sturm Dominik, Hench Jürgen, Frank Stephan, Krskova Lenka, Vicha Ales, Zapotocky Michal, Bison Brigitte, Castel David, Grill Jacques, Debily Marie-Anne, Harter Patrick N, Snuderl Matija, Kramm Christof M, Reifenberger Guido, Korshunov Andrey, Jabado Nada, Wesseling Pieter, Wick Wolfgang, Solomon David A, Perry Arie, Jacques Thomas S, Jones Chris, Witt Olaf, Pfister Stefan M, von Deimling Andreas, Jones David T W, Sahm Felix
Abstract excerpt
BACKGROUND: Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the epidermal growth factor receptor gene (EGFR) have recently been identified in a distinct subset of pediatric-type bithalamic gliomas with a unique DNA methylation pattern. METHODS: Here, we investigated an epigenetically homogeneous cohort of malignant...
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