Article

Establishing the molecular basis for MDA5 mutation-linked autoimmunity

2026-01-20

Abstract excerpt

Melanoma differentiation-associated protein 5 (MDA5), a member of the RIG-I-like receptor family, is a cytoplasmic sensor essential for innate antiviral immunity. MDA5 distinguishes viral RNA from host RNA in part through its ATP hydrolysis activity, which promotes filament turnover on shorter endogenous dsRNAs. Here, we show that the gain-of-function T331I disease-linked mutation within the ATP binding pocket dis...

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Literature Corpus work: 5f01deb8-222c-5621-b426-98f2f0239c3d
DOI: 10.64898/2026.01.20.700587

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