Article

Integrative structural analysis of NF45-NF90 heterodimers reveals architectural rearrangements and oligomerisation on binding dsRNA

2024-08-19

Abstract excerpt

Complexes of nuclear factors 45 and 90 (NF45-NF90) play a multitude of roles in co- and post-transcriptional RNA processing, including regulating adenosine-to-inosine editing, cassette exon and back splicing, and splicing fidelity. NF45-NF90 complexes recognise dsRNA and, in human cells, primarily interact with inverted Alu repeats (AluIRs) that are commonly inserted into introns and other non-coding RNA regions....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 316980fd-d41c-54e6-953f-0c5f298faaf5
DOI: 10.1101/2024.08.19.607423

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative structural analysis of NF45-NF90 heterodimers reveals architectural rearrangements and oligomerisation on binding dsRNADOI 10.1101/2024.08.19.607423Read

MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNASemantic proximity Read

Molecular basis of autoimmune disease protection by MDA5 variantsSemantic proximity Read

Blending and separating dynamics of RNA-binding proteins develop architectural splicing networks spreading throughout the nucleus.Semantic proximity Read

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.Semantic proximity Read

Establishing the molecular basis for MDA5 mutation-linked autoimmunitySemantic proximity Read

Unique conformational dynamics and protein recognition of A-to-I hyper-edited dsRNASemantic proximity Read

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates SplicingSemantic proximity Read

The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.Semantic proximity Read

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.Semantic proximity Read

Optimized photochemistry enables efficient analysis of dynamic RNA structuromes and interactomes in genetic and infectious diseases.Semantic proximity Read

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.Semantic proximity Read

Dissection of purified LINE-1 reveals distinct nuclear and cytoplasmic intermediatesSemantic proximity Read