Article

Molecular basis of autoimmune disease protection by MDA5 variants

2024-10-03

Abstract excerpt

MDA5 recognizes dsRNA from viruses and retroelements. Cooperative filament formation and ATP-dependent proofreading confer MDA5 with the necessary sensitivity and specificity for dsRNA. The gene encoding MDA5 is a hotspot for disease-associated variants. Many MDA5 variants are associated with protection from autoimmune disease, while increasing the risk of infection and chronic inflammation, but how these variants...

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Literature Corpus work: adffc78e-b0fe-5e0a-84b8-2ce7ec3e0718
DOI: 10.1101/2024.10.03.616466

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