Article
TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology.
Molecular cell - 3 Dec 2020
Chen Shasha, Liu Shengduo, Wang Junxian, Wu Qirou, Wang Ailian, Guan Hongxin, Zhang Qian, Zhang Dan, Wang Xiaojian, Song Hai, Qin Jun, Zou Jian, Jiang Zhengfan, Ouyang Songying, Feng Xin-Hua, Liang Tingbo, Xu Pinglong
Abstract excerpt
Mitochondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate. It remains unknown whether innate nucleic acid sensing, the central and general mechanisms of monitoring both microbial invasion and cellular damage, can reprogram and govern mitochondrial dynamics and function. Here, we unexpectedly observed that upon activation of RIG-I-like receptor (RLR)-MAVS signaling,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.