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Article

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.

Science (New York, N.Y.) - 8 Feb 2013

Motz Carina, Schuhmann Kerstin Monika, Kirchhofer Axel, Moldt Manuela, Witte Gregor, Conzelmann Karl-Klaus, Hopfner Karl-Peter

Abstract excerpt

The retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) melanoma differentiation-associated protein 5 (MDA5) senses cytoplasmic viral RNA and activates antiviral innate immunity. To reveal how paramyxoviruses counteract this response, we determined the crystal structure of the MDA5 adenosine 5'-triphosphate (ATP)-hydrolysis domain in complex with the viral inhibitor V protein. The V protein unfolded the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23328395
DOI: 10.1126/science.1230949

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