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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

1 May 2022

Abstract excerpt

The protein TRIM5α has multiple roles in antiretroviral defense, but the mechanisms underlying TRIM5α action are unclear. Here, we employ APEX2-based proteomics to identify TRIM5α-interacting partners. Our proteomics results connect TRIM5 to other proteins with actions in antiviral defense. Additionally, they link TRIM5 to mitophagy, an autophagy-based mode of mitochondrial quality control that is compromised in...

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PMID: 35545034
DOI: 10.1016/j.celrep.2022.110797

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