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Article

The central helicase domain holds the major conformational epitopes of melanoma differentiation–associated gene 5 autoantibodies

8 Aug 2023

Abstract excerpt

OBJECTIVE: Autoantibodies against MDA5 (melanoma differentiation-associated protein 5) serve as a biomarker for DM (dermatomyositis) and indicate a risk factor for interstitial lung disease (ILD). MDA5 is a protein responsible for sensing RNA virus infection and activating signalling pathways against it. However, little is known about the antigen epitopes on MDA5 autoantibodies. We aimed to determine the...

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PMID: 37551942
DOI: 10.1093/rheumatology/kead397

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