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Article

RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.

Molecular cell - 12 Sept 2013

Peisley Alys, Wu Bin, Yao Hui, Walz Thomas, Hur Sun

Abstract excerpt

Retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are paralogous receptors for viral double-stranded RNA (dsRNA) with divergent specificity. We have previously shown that MDA5 forms filaments upon viral dsRNA recognition and that this filament formation is essential for interferon signal activation. Here, we show that while RIG-I binds to a dsRNA end as a monomer in...

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Identifiers

PMID: 23993742
DOI: 10.1016/j.molcel.2013.07.024

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MAVS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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