HNRNPA0 Acts as a Master Upstream Regulator of NF-κB to Drive Oncogenic Phenotypes in Oral Squamous Cell Carcinoma.

Abstract excerpt

BACKGROUND: Oral squamous cell carcinoma (OSCC) remains a lethal malignancy with a 5-year survival rate below 50%, necessitating the identification of novel therapeutic targets. While the RNA-binding protein HNRNPA0 is implicated in various cancers, its precise role and mechanism in OSCC pathogenesis are undefined. METHODS: HNRNPA0 expression was assessed using TCGA data, clinical OSCC specimens (n = 10) and cell...

Topics

• Humans
• Mouth Neoplasms
• NF-kappa B
• Carcinoma, Squamous Cell
• Animals
• Cell Proliferation