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Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role of <i>SPP1</i> <sup>+</sup> macrophages

2024-07-10

Abstract excerpt

Hypopharyngeal squamous cell carcinoma (SCC) is a highly aggressive cancer with a poor prognosis, particularly in advanced stages where concurrent chemoradiotherapy (CCRT) is used for treatment. However, resistance to CCRT poses a significant challenge, often leading to treatment failure and disease progression. This study explores the tumor microenvironment (TME) of hypopharyngeal SCC to understand the molecular...

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Literature Corpus work
526df42d-19ec-594e-9fcb-a757f1433cb7
DOI
10.1101/2024.07.09.602476
Open publication

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Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role of <i>SPP1</i> <sup>+</sup> macrophagesDOI 10.1101/2024.07.09.602476
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